Immunological factor development of external genital endometriosis

External genital endometriosis (EGE) is one of the common gynecological diseases women reproductive age with a relapsing, progressive course that worsens quality life patients due to pain, emotional imbalance, fear relapse and possible surgical intervention. Currently, recognized as most associated infertility. Thus, among fertile preserved childbearing function, disease generally diagnosed in approximately 6-7%, while suffering from infertility, its frequency can reach 20-48%. However, causes determine dysfunction EGE are not well understood. Much attention currently paid role immunity formation endometriosis. Patients show changes both local factors immunological components circulating blood. Purpose study: study innate adaptive external (EGE). The included 71 various stages endometriosis, control group 24 without Determination population composition peripheral blood lymphocytes, level monocytes expressing TLR, activation markers, was carried out by laser flow cytometry — Immunotex (France), Caltag (USA), FITC (fluorescein isothiocynate) labeled CD3, CD4, CD8, CD16, CD19, HLA-DR, CD282, CD284 PE (phycoerythrin) - CD25, CD69, CD95, CD107a, CD14. characterized by: at I-II violation early immune response (an increase number TLR-4, differentiation processes immunocompetent cells, which reflected decrease expression CD16 + HLA-DR , CD107a CD8 III-IV disease, there markers on their surface, combined HLADR surface. CD95 were found EGE. results obtained allow us understand features functioning studied parameters be used diagnostic criteria for These data serve theoretical basis further identification progression, mechanisms underlying inflammation.